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芮蒙杰 副教授

编辑: 太阳2官方注册登录:2019-06-14 点击数:

   

主要研究方向

近年来从事新型的多功能生物材料研究,结合多学科交叉研究的优势,通过结构设计和可控修饰得到模拟生物活性的大分子材料,在靶向药物输送、肿瘤治疗和多模态生物影像等多个领域进行综合应用,并证明了这些大分子材料在提高肿瘤治疗的特异性和有效性、实现精准治疗等方面具有独特的优势。在国际学术期刊上发表多篇学术论文,其中包括Molecular PharmaceuticsInternational journal of pharmaceutics等药剂领域专业期刊。研究成功先后获得国家自然科学青年基金、江苏省自然科学青年基金以及面上项目等项目资助。

主要研究方向及兴趣包括:

1. 新型仿生纳米材料的开发及其在药物输送、治疗研究和生物成像上的应用

2. 多功能敏感型纳米材料在生物成像、肿瘤治疗与联合治疗上的应用

受教育及研究工作经历

2017.05-至今,江苏大学,太阳2官方注册登录,药剂学系,副教授

2013.03-2017.04 江苏大学,太阳2官方注册登录,药剂学系,讲师

2008.09-2012.12,上海交通大学,生命科学技术学院,生物医学工程,博士,导师:徐宇虹教授

2004.09-2008.06,上海交通大学,生命科学技术学院,生物工程,学士

主要科研项目

1、江苏省自然科学基金面上项目(BK20181445),201807-202106,主持。

2、国家自然科学基金青年科学基金项目(81402880),201501-201712,主持。

3、江苏省自然科学基金青年项目(BK20130541),201307-201607,主持。

4、江苏大学高级人才科研启动基金(14JDG163),201407-202006,主持。

5、国家自然科学基金青年科学基金项目(81102395),201201-201412,参加。

招生方向:

热忱欢迎有志从事科研工作的本科生、研究生到大家课题组学习工作。欢迎具有药学、生物医学、化学以及材料背景的同学报考。有疑问可邮件联系

讲授课程:

制剂工程学

工业药剂学

Preparation Equipment and Process Design Workshop(海外教育学院)

Industrial Pharmaceutics(海外教育学院)

Pharmaceutical Molecular Biology(海外教育学院)

  

代表性论文:

1. Chunlai Feng, Haisheng Zhang, Jiaming Chen, Siqi Wang, Yuanrong Xin, Yang Qu, Qi Zhang, Wei Ji, Fumiyoshi Yamashita, and Mengjie Rui*. Ratiometric Co-Encapsulation and Co-Delivery of Doxorubicin and Paclitaxel by Tumor-Targeted Lipodisks for Combination Therapy of Breast Cancer. International journal of pharmaceutics, 560 (2019): 191-204.

2. Chunlai Feng, Xianqin Yuan, Kexin Chu, Haisheng Zhang, Wei Ji, and Mengjie Rui*. Preparation and Optimization of Poly (Lactic Acid) Nanoparticles Loaded with Fisetin to Improve Anti-Cancer Therapy. International journal of biological macromolecules, 125 (2019): 700-10.

3. Hailing Tang, Mengjie Rui, Chuang Yu, Tao Chu, Chao Li, Zhenzhen Zhan, Hao Cao, Hangwen Li, Zhongmin Liu, and Haifa Shen. Nanotechnology in Generation and Biomedical Application of Induced Pluripotent Stem Cells. Nano Life, 8, no. 04 (2018): 1841002.

4. Qi Zhang, Jian Zhang, Song Xue, Mengjie Rui, Bin Gao, Ang Li, Jiashuai Bai, Zhichao Yin, and Ebubedike Mitchelle Anochie. Enhanced Enantioselectivity of Native Α‐Cyclodextrins by the Synergy of Chiral Ionic Liquids in Capillary Electrophoresis. Journal of separation science, 41, no. 24 (2018): 4525-32.

5. Chunlai Feng#, Mengjie Rui#, Haijun Shen, Yuanrong Xin, Jie Zhang, Jun Li, Lixiang Yue, Wenlong Lai, Ximing Xu*.Tumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancer, International Journal of Pharmaceutics, 2017, 528 (1-2):322-333.

6. Mengjie Rui#, Yuanrong Xin , Ran Li, Yanru Ge, Chunlai Feng*, and Ximing Xu*. Targeted Biomimetic Nanoparticles for Synergistic Combination Chemotherapy of Paclitaxel and Doxorubicin, Molecular Pharmaceutics, 2017, 14 (1): 107-123.

7. Mengjie Rui#, Yang Qu, Tong Gao, Yanru Ge, Chunlai Feng*, and Ximing Xu*. Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells, International Journal of Nanomedicine, 2017, 12: 217-237.

8. Mengjie Rui#, Hailing Tang, Yan Li, Xiaohui Wei, and Yuhong Xu*. Recombinant High Density Lipoprotein Nanoparticles for Target-Specific Delivery of siRNA. Pharmaceutical research, 2013, 30 (5): 1203-14.

9. Mengjie Rui#, Wei Guo, Qian Ding, Xiaohui Wei, Jianrong Xu, and Yuhong Xu*. Recombinant high-density lipoprotein nanoparticles containing gadolinium-labeled cholesterol for morphologic and functional magnetic resonance imaging of the liver. International journal of nanomedicine, 2012, 7: 3751-3768.

10. Hailing Tang, Xiaojing Chen, Mengjie Rui, Wenqiang Sun, Jian Chen, Jinliang Peng, and Yuhong Xu*. Effects of surface displayed targeting ligand GE11 on liposome distribution and extravasation in tumor. Molecular Pharmaceutics, 2014, 11 (10): 3242–3250.

11. Yan Li, Mengjie Rui, Hailing Tang, and Yuhong Xu*. The distribution and cell uptake of ApoA1 modified lipid carriers of siRNA in mouse liver in vivo. Asian Journal of Pharmaceutical Sciences, 2013, 8: 228-233.

12. Junhua Mai, Shuxian Song, Mengjie Rui, Dan Liu, Qian Ding, Jinliang Peng, Yuhong Xu*. A synthetic peptide mediated active targeting of cisplatin liposomes to Tie2 expressing cells. Journal of Controlled Release, 2009, 139 (3): 174–181. 2009.

13. Xiaomeng Zhang*, Huanjun Yang*, Ke Gu, Jian Chen, Mengjie Rui, and Guo-Liang Jiang. In vitro and in vivo study of a nanoliposomal cisplatin as a radiosensitizer. International journal of nanomedicine, 2011, 6: 437-444.

联系方式:

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E-mail: mjrui@ujs.edu.cn

 

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