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魏渊 教授

编辑: 太阳2官方注册登录:2020-06-17 点击数:

学位博士

职称:教授

工作经历:

20103月至今江苏大学太阳2官方注册登录

20045—20102月美国纽约州卫生部Wadsworth研究中心研究助理(博士生)

教育背景:
19999—20037月南京大学生物化学专业学士
20039—20102月美国纽约州立大学Albany分校公共卫生学院毒理学专业博士

研究方向:
细胞色素 P450 酶系相关的药物代谢与毒理,分子生药学

学术兼职:

国际药物代谢学会(ISSX)会员

中华中医药学会中药毒理与安全性评价分会委员

中国中西医结合学会分子生药学专业委员会委员

基金项目(主持):

1. 2014-2017  国家自然科学基金 (面上项目)    项目名称:基于TALEN技术的细胞色素P450基因敲除大鼠模型的构建与应用 项目代码:81373480

2. 2012-2014  国家自然科学基金(青年项目)项目名称:基于XH-CL基因敲除小鼠模型的雷公藤内酯醇肝外组织代谢与毒理研究 项目代码:81102522

3. 2012-2014   江苏省自然科学基金项目名称:肝外细胞色素P450代谢在雷公藤内酯醇多系统毒性中的作用研究 项目代码:BK2011473

4. 江苏省青蓝工程青年骨干教师

5. 江苏省博士后科研资助计划(1201081C

6. 江苏大学高级人才基金

代表性论文:

1. Zhou H, Yang L, Wang C, Li Z, Ouyang Z, Shan M, Gu J*, Wei Y*. CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. Drug Metab Dispos. 2019 accepted.

2. Ye H, Sui D, Liu W, Yuan Y, Ouyang Z, Wei Y*. Effects of CYP2C11 Gene Knockout on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats. Xenobiotica. 2019 Dec; 49(12):1478-1484.

3. Liu W, Sui D, Ye H, Ouyang Z, Wei Y*. CYP2C11 played a significant role in down-regulating rat blood pressure under the challenge of a high-salt diet. PeerJ. 2019 Apr; 7: e6807.

4. Wei Y, Wang L, Wang D, Wang D, Wen C, Han B, Ouyang Z*. Characterization and anti-tumor activity of a polysaccharide isolated from Dendrobium officinale grown in the Huoshan County. Chin Med. 2018 Sep; 13: 47.

5. Wei Y*, Wang D, Chen M, Ouyang Z, Wang S, Gu J*. Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity. Chin Med. 2018 Apr; 13: 23.

6. Wei Y*, Yang L, Zhang X, Sui D, Wang C, Wang K, Shan M, Guo D, Wang H. Generation and Characterization of a CYP2C11-null Rat Model by using the CRISPR/Cas9 method. Drug Metab Dispos. 2018 May; 46(5):525-531.

7. Wei Y*, Sui D J, Xu H M, et al. Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects.[J]. Chinese Journal of Natural Medicines, 2017, 15(12):905-911.

8. Wang D, Wang K, Sui D, Ouyang Z, Wei Y*. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice[J]. Chemico-Biological Interactions, 2017, 268: 47-52.

9. Li L, Megaraj V, Wei Y, et al. Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse[J]. Carcinogenesis, 2014, 35(11): 2584-2591.

10. Wei Y, Li L, Zhou X, Zhang QY, Dunbar A, Liu F, Kluetzman K, Yang W, Ding X.Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug MetabDispos. 2013 Jan;41(1):132-40.

11. Li L, Wei Y, Zhou X, et al. Characterization of a Cyp2a (4/5) bgs-null Mouse Model: Role of CYP2A and CYP2B in Nicotine Metabolism[J]. The FASEB Journal, 2012, 26(1 Supplement): 1052.3-1052.3.

12. Wei Y, Wu H, Li L, Liu Z, Zhou X, Weng Y, D'Agostino J, Ling G, Zhang L, Kluetzman K, Yao Y, Zhang QY, and Ding X Generation and characterization of a CYP 2A 13/2B6/ 2F 1 -transgenic mouse model. Drug MetabDispos. 2012 Jun;40(6):1144-50.

13. Cao X, Deng W, Wei Y, Yang Y, Su W, Wei Y, Xu X, Yu J.IncorporatingpTGF-β1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells for chondrogenicdifferentiation.Eur Cell Mater. 2012 Feb 7;23:81-93.

14. Li L#, Wei Y#, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and characterization of a Cyp 2f 2-null mouse and studies on the role of CYP 2F 2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J PharmacolExpTher.2011 Oct;339(1):62-71. (# 并列第一编辑 ).

15. Tong S, Chu C, Wei Y , Wang L, Gao X, Xu X, Yu J.Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. J Pharm Pharmacol.2011 Feb;63(2):238-44.

16. Zhou X, Wei Y, Xie F, Laukaitis CM, Karn RC, Kluetzman K, Gu J, Zhang QY, Roberts DW, Ding X. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP 2A 5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. MolPharmacol.2011 Apr;79(4):710-23.

17. Wei Y , Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X.Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J PharmacolExpTher.2010 Jul;334(1):69-77.

18. 王长锁,王凯,孟欣,欧阳臻,戴军,陈乃富,韩邦兴,魏渊. 霍山石斛对小鼠肝脏细胞色素P450酶表达和活性的影响[J].中国中药杂志,2018,43(21):4323-4329.(通讯编辑)

19. 王凯, 眭丹娟, 王长锁, 杨丽, 欧阳臻, 陈乃富, 韩邦兴, 魏渊. (2017). 5 种石斛对四氯化碳致小鼠急性肝损伤的保护作用. 中国中药杂志, 42(10), 1945-1950.  (通讯编辑)

20. 袁媛, 魏渊, 于军等. 表观遗传与药材道地性研究探讨[J]. 中国中药杂志, 2015, 40(13): 2679-2683.

21. 王笃军, 王硕, 严峰, 王国斌, 许海玉, 欧阳臻,  魏渊. (2017). 欧前胡素和异欧前胡素对小鼠肝 CYP450 的影响. 中成药, 39(1), 14-20.    (通讯编辑)

22. 吴娜, 刘星雨, 王笃军, 罗盼, 吴瑶,  魏渊. (2014). 雷公藤内酯醇对 C57BL/6 小鼠亚慢性毒性作用的研究. 中成药, 36(5), 904-908.      (通讯编辑)

23. 刘星雨, 吴娜, 张娇, 吴瑶, 罗盼, 王伟男, 魏渊. (2014). , 炙甘草对小鼠 CYP3As 及对雷公藤内酯醇解毒的比较. 中成药, 36(12), 2451-2457.    (通讯编辑)

24. 《分子生药学(第三版)》 科学出版社 编委

中国发明专利(授权)

吸烟人群肺癌风险相关细胞色素P450基因检测芯片(专利号:ZL201110123137.2

 

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