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张业旺 教授

编辑: 太阳2官方注册登录:2019-06-13 点击数:

    

 l 基本情况:

男,教授,硕士生导师,197410月生于湖北十堰。江苏大学天智绿业药物研究所所长。从事制药工程和酶工程方向的研究。20089月受韩国Brain Pool项目资助,赴韩国Konkuk University做博士后研究,在20093月至20108月在该校受聘担任Assistant Professor。主持及参与完成国家自然科学基金等多项基金项目,已经发表SCI文章50余篇,被引近千次,单篇被引最高超200次。以第一编辑或通讯编辑共发表SCI收录文章40余篇,H因子192019.5),I10因子33谷歌 Scholar)。ORCID: 0000-0003-0873-0721  

l 教育经历

2002.09-2006.03,华东理工大学,博士,生物化工。

1997.09-2000.06,大连理工大学,硕士,生物化工。

1993.09-1997.06,武汉工程大学,学士,有机化工。

l 工作经历:

2015.07至今,教授,江苏大学

2008.09-2010.08PostdocAssistant professorKonkuk University, 韩国

2006.06-2015.07,讲师,副教授,江苏大学

2000.06-2002.08,研发工程师,石家庄制药集团

l 研究方向:

生物催化与转化,制药过程工程。主要包括: (1) 重要药物中间体的生物法生产新技术开发; (2) 重要生物催化剂的筛选与制备; (3) 制药过程集成化技术。

招收生药学、药物化学研究方向的学术型研究生以及制药工程专业学位研究生,欢迎具有制药工程、药学、化学、化学工程及生物学等相关学习背景的同学报考。

联系方式:Email: zhangyewang@ujs.edu.cn; 太阳2官方注册登录2211室。

l 学术兼职

担任Journal of Microbiology and Biotechnology (IF2017=1.65)的编委(Editorial Board)。

担任Chemical Engineering Journal, ACS Applied Materials & Interfaces, Bioresource Technology, Materials Science & Engineering C, Applied Surface Science, International Journal of Biological Macromolecules, Applied Microbiology and Biotechnology, Process Biochemistry, Scientific Reports, Enzyme and Microbial Technology, Molecular Catalysis, Materials Chemistry and Physics, Journal of Nanoparticle Research, Applied Biochemistry and Biotechnology, European Food Research and Technology, BMC Pharmacology and Toxicology, Biocatalysis and Biotransformation, Biocatalysis and Agricultural Biotechnology, Spectroscopy Letters, Preparative Biochemistry and Biotechnology, Instrumentation Science and Technology, International Journal of Nanomedicine, Journal of Scientific and Industrial Research, Nanoscience and Nanotechnology Letters, Journal of Nanoscience and NanotechnologySCI期刊的审稿人。

l 已发表的代表性论文:

1. Fei-Long Li, Qiang Zhou, Wei Wei, Jian Gao, Ye-Wang Zhang*. Switching the substrate specificity from NAD to NADP by a single mutation of NADH oxidase from Lactobacillus rhamnosus. International Journal of Biological Macromolecules. 2019. 135: 328-336. DOI: 10.1016/j.ijbiomac.2019.05.146

2. Fei-Long Li, Qing-Lan Tao, Cai-Yun Liu, Jian Gao, Ye-Wang Zhang*. Role of introduced surface cysteine of NADH oxidase from Lactobacillus rhamnosus. International Journal of Biological Macromolecules. 2019, 132: 150-156. DOI: 10.1016/j.ijbiomac.2019.03.168

3. Yi-Hao Zhu, Cai-Yun Liu, Sha Cai, Li-Bin Guo, In-Won Kim, Vipin C Kalia*, Jung-Kul Lee*, Ye-Wang Zhang*. Cloning, expression and characterization of a highly active alcohol dehydrogenase for efficient production of (S)-ethyl-4-chloride-3-hydroxybutyrate. Indian Journal of Microbiology, 2019, 59: 225-233. DOI: 10.1007/s12088-019-00795-0

4. Fei-Long Li#, Meng-Yao Zhuang#, Jia-Jia Shen, Xiao-Man Fan, Hyunsoo Choi, Jung-Kul Lee*, Ye-Wang Zhang*. Specific immobilization of recombinant E. coli on mannose functionalized magnetic nanoparticles. Catalysts, 2019, 9: 7. DOI: 10.3390/catal9010007

5. Hui Gao, Dakshinamurthy Sivakumar, Tae-Su Kim, Sanjay K. S. Patel, Vipin C Kalia, In-Won Kim*, Ye-Wang Zhang*, Jung-Kul Lee*. NADH oxidase from Lactobacillus reuteri: a versatile enzyme for oxidized cofactor regeneration. International Journal of Biological Macromolecules. 2019, 123: 629-636. DOI: 10.1016/j.ijbiomac.2018.11.096.

6. Meng-Qiu Xu, Shuang-Shuang Wang, Li-Na Li, Jian Gao*, Ye-Wang Zhang*. Combined cross-linked enzyme aggregates as biocatalysts. Catalysts. 2018, 8: 460. DOI: 10.3390/catal8100460.

7. Jian Gao, Chun-Liu Lu, Yue Wang, Shuang-Shuang Wang, Jia-Jia Shen, Jiu-Xun Zhang, Ye-Wang Zhang*. Rapid immobilization of cellulase onto graphene oxide with a hydrophobic spacer. Catalysts. 2018, 8: 180. DOI: 10.3390/catal8050180

8. Meng-Yao Zhuang#, Xiao-Ping Jiang#, Xiao-Min Ling, Meng-Qiu Xu, Yi-Hao Zhu, Ye-Wang Zhang*. Immobilization of NADH oxidase and glycerol dehydrogenase for enzymatic synthesis of 1,3-dihydroxyacetone with in situ cofactor regeneration. Journal of Chemical Technology and Biotechnology. 2018, 93: 2351-2358. DOI: 10.1002/jctb.5579

9. Fei-Long Li, Ying Shi, Jiu-Xun Zhang, Jian Gao, Ye-Wang Zhang*. Cloning, expression, characterization and homology modeling of a novel H2O-forming NADH oxidase from Streptococcus mutans ATCC 25175. International Journal of Biological Macromolecules. 2018, 113: 1073-1079. DOI: 10.1016/j.ijbiomac.2018.03.016

10. Jian Gao, Ai-Rong Wang, Xiao-Ping Jiang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of glycerol dehydrogenase onto epoxy-nanoparticles. Journal of Nanoscience and Nanotechnology. 2018, 18: 4852-4857. DOI: 10.1166/jnn.2018.15266.

11. Meng-Yao Zhuang, Cong Wang, Meng-Qiu Xu, Xiao-Min Ling, Jia-Jia Shen, Ye-Wang Zhang*. Using concanavalinA as a spacer for immobilization of E. coli onto magnetic nanoparticles. International Journal of Biological Macromolecules. 2017, 104: 63-69. DOI: 10.1016/j.ijbiomac.2017.05.150

12. Guo-Hua Xia, Wei Liu, Xiao-Ping Jiang, Xiang-Yu Wang, Ye-Wang Zhang*, Jianyong Guo. Modification of Fe3O4@SiO2 magnetic nanoparticles for immobilization of lipase. Journal of Nanoscience and Nanotechnology. 2017, 17: 370-376. DOI: 10.1166/jnn.2017.10964

13. Meng-Yao Zhuang, Qian-Liu Zhou, Xiang-Yu Wang, Jun-Xi Zhang, Lan Xue, Ru Wang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of lipase onto dopamine functionalized magnetic nanoparticles. Nanoscience and Nanotechnology Letters, 2016, 8: 251-254. DOI: 10.1166/nnl.2016.2127

14. Xiao-Ping Jiang, Ting-Ting Lu, Cai-Hong Liu, Xiao-Ming Ling, Meng-Yao Zhuang, Jiu-Xun Zhang, Ye-Wang Zhang*. Immobilization of alcohol dehydrogenase onto epoxy-functionalized Fe3O4@SiO2 nanoparticles for synthesis of (R)-mandelic acid. International Journal of Biological Macromolecules. 2016, 88: 9-17. DOI: 10.1016/j.ijbiomac.2016.03.031

15. Cai-Hong Liu, Xiao-Qian Li, Xiao-Ping Jiang, Meng-Yao Zhuang, Xiao-Min Ling, Jiu-Xun Zhang, Chun-Hai Bao, Ye-Wang Zhang*. Preparation of functionalized graphene oxide nanocomposites for covalent immobilization of NADH oxidase. Nanoscience and Nanotechnology Letters. 2016, 8: 164-167, DOI: 10.1166/nnl.2016.2102

16. Xiao-Min Ling#, Xiang-Yu Wang#, Ping Ma, Yi Yang, Jie-Mei Qin, Xue-Jun Zhang, Ye-Wang Zhang*. Covalent immobilization of penicillin G acylase onto Fe3O4@Chitosan magnetic particles. Journal of Microbiology and Biotechnology, 2016, 26: 829-836. DOI: 104014/jmb.1511.11052

17. Qing-Lan Tao, Yue Li, Ying Shi, Rui-Jiang Liu, Ye-Wang Zhang*, Jianyong Guo. Application of molecular imprinted magnetic Fe3O4@SiO2 nanoparticles for selective immobilization of cellulase. Journal of Nanoscience and Nanotechnology. 2016, 166055-6060. DOI: 10.1166/jnn.2015.10853

18. Ying Shi, Wei Liu, Qing-Lan Tao, Xiao-Ping Jiang, Cai-Hong Liu, Sha Zeng, Ye-Wang Zhang*. Immobilization of lipase by adsorption onto magnetic nanoparticles in organic solvents. Journal of Nanoscience and Nanotechnology. 2016, 16: 601-607 DOI: 10.1166/jnn.2015.10694

19. Xiaoyun Zhang*, Ye-Wang Zhang*, Hongyin Zhang, Qiya Yang, Haiying Wang, Guochao Zhang. Preparation, characterization and antibacterial activity of octenyl succinic anhydride modified inulin. International Journal of Biological Macromolecules. 2015, 78: 79-86. DOI: 10.1016/j.ijbiomac.2015.03.067

20. Xiang-Yu Wang#, Xiao-Ping Jiang#, Yue Li, Sha Zeng, Ye-Wang Zhang*. Preparation Fe3O4@Chitosan magnetic particles for covalent immobilization of lipase from Thermomyces lanuginosus. International Journal of Biological Macromolecules. 2015, 75: 44-50. DOI: 10.1016/j.ijbiomac.2015.01.020

21. Yue Li, Xiang-Yu Wang, Xiao-Ping Jiang, Jing-Jing Ye, Ye-Wang Zhang*, Xiao-Yun Zhang. Fabrication of graphene oxide decorated with Fe3O4@SiO2 for immobilization of cellulase. Journal of Nanoparticle Research, 2015, 17: 8. DOI: 10.1007/s11051-014-2826-z

22. Yue Li, Xiang-Yu Wang, Rui-Zhuo Zhang, Xiao-Yun Zhang, Xi-Ming Xu, Ye-Wang Zhang*. Molecular imprinting and immobilization of cellulase onto magnetic Fe3O4@SiO2 nanoparticles. Journal of Nanoscience and Nanotechnology. 2014, 14: 2931-2936. DOI:10.1166/jnn.2013.8625

23. Wei Liu, Fang Zhou, Xiao-Yun Zhang, Yue Li, Xiang-Yu Wang, Xi-Ming Xu, Ye-Wang Zhang*. Preparation of magnetic Fe3O4@SiO2 nanoparticles for immobilization of lipase. Journal of Nanoscience and Nanotechnology. 2014, 14: 3068-3072. DOI:10.1166/jnn.2013.8567

24. Jianfeng Wang, Wei Liu, Baoquan Liu, Shengdi Fan, Ye-Wang Zhang*. Analyzing increased fluorescence of single quantum dots on dehydrated agarose by single-molecular imaging. Spectroscopy Letters. 2013, 46: 195-200. DOI: 10.1080/00387010.2012.700544

25. Ye-Wang Zhang, Manish Kumar Tiwarri, Hui Gao, Marimuthu Jeya, Jung-kul Lee*. Cloning and characterization of a thermostable H2O-forming NADH oxidase from Lactobacillus rhamnosus. Enzyme and Microbial Technology. 2012, 50: 255-262. DOI: 10.1016/j.enzmictec.2012.01.009

26. Ye-Wang Zhang, Manish Kumar Tiwarri, Marimuthu Jeya, Jung-kul Lee*. Covalent immobilization of recombinant Rhizobium etli CFN42 xylitol dehydrogenase onto modified silica nanoparticles. Applied Microbiology and Biotechnology. 2011, 90: 499-507. DOI: 10.1007/s00253-011-3094-9

27. Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. Enhanced activity and stability of L-arabinose isomerase by immobilization on aminopropyl glass. Applied Microbiology and Biotechnology. 2011, 89: 1435-1442. DOI: 10.1007/s00253-010-2966-8

28. Ye-Wang Zhang*, Rui-Jiang Liu, Xi-Ming Xu*. One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+. Applied Microbiology and Biotechnology, 2010, 88:49-55. DOI: 10.1007/s00253-010-2727-8

29. Ye-Wang Zhang, Marimuthu Jeya, Jung-Kul Lee*. L-Ribulose production by an Escherichia coli harboring L-arabinose isomerase from Bacillus licheniformis. Applied Microbiology and Biotechnology, 2010, 87: 1993-1999. DOI: 10.1007/s00253-010-2600-9

30. Ye-Wang Zhang, Ponnandy Prabhu, Jung-Kul Lee*. Alginate immobilization of recombinant Escherichia coli whole cells harboring L-arabinose isomerase for L-ribulose production. Bioprocess and Biosystems Engineering, 2010, 33: 741-748. DOI: 10.1007/s00449-009-0397-7

20196月更新)


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