Yuan Wei

Time2019-11-27 Onclick

Wei,Yuan

Office Address:

Room 1309, School of Pharmacy

Jiangsu University,

Zhenjiang, Jiangsu,212013, CHINA

Tel: +86-88791526

Email: ywei@ujs.edu.cn

Education:

Aug. 2003 ~ Feb. 2010, Dept. of Environmental Health Sciences, School of Public Health, State University of New York at Albany Ph.D. in Environmental Health and Toxicology; Advisor: Prof. Xinxin Ding

Sep. 1999 ~ Jul. 2003, Dept. of Biochemistry, School of Life Sciences, Nanjing University B.S. in Biochemistry

Research Projects (Principal Investigator):

1.Generation and application of cytochrome P450 knockout rat models with TALEN cleavage.supported by National Natural Science Foundation of China(Grant # 81373480,Principal Investigator)

2.Toxicological studies of triptolide in extra-hepatic tissues based onaXh-CL mouse model.supported by National Natural Science Foundation of China (Grant #81102522, Principal Investigator)

3.The role of extra-hepatic cytochrome P450 metabolism in the systemic toxicity of Triptolide.supported by National Natural Science Foundation of Jiangsu Province,China(Grant #BK2011473,Principal Investigator)

4. JiangsuProvince Postdoctoral Research Funds(Grant #1201081C)

Publications:

1.Wei Y, Yang L, Zhang X, Sui D, Wang C, Wang K, Shan M, Guo D, Wang H. Generation and Characterization of a CYP2C11-null Rat Model by using the CRISPR/Cas9 method. Drug Metab Dispos. 2018 Feb 14. pii: dmd.117.078444. doi: 10.1124/dmd.117.078444.

2.Wei Y, Sui D J, Xu H M, et al. Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects.[J]. Chinese Journal of Natural Medicines, 2017, 15(12):905-911.

3.Wang D, Wang K, Sui D, Ouyang Z, Wei Y. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice[J]. Chemico-Biological Interactions, 2017, 268: 47-52.

4.WANG Du-jun, WANG Shuo, YAN Feng, WANG Guo-bin, XU Hai-yu, OUYANG Zhen, WEI Yuan. Effects of imperatorin and isoimperatorin on liver cytochrome P450s in mice. Chinese Traditional Patent Medicine.2017, 39(1)14-20.

5.Li L, Megaraj V, Wei Y, et al. Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse[J]. Carcinogenesis, 2014, 35(11): 2584-2591.

6.YUAN YuanWEI YuanYU JunHUANG Lu-qi. Relationship of epigenetic and Dao-di herbs.China Journal of Chinese Materia Medica. 2015, 40(13): 2679-2683.

7.WANG KaiSUI Dan-juan, WANG Chang-suo, YANG Li, OUYANG Zhen, CHEN Nai-fu, HAN Bang-xing, WEI Yuan. Protective effects of five different types of Dendrobium on CCl4-induced liver injury in mice. China Journal of Chinese Materia Medica.2017, 42(10):1945-1950.

8.WU Na, LIU Xing-yu, WANG Du-jun, LUO Pan, WU Yao, WEI Yuan.Sub-chronic toxicities of triptolide to C57BL /6 mice. Chinese Traditional Patent Medicine.2014, 36(5):904-908.

9.LIU Xing-yu,WUNa,ZHANGJiao,WUYao,LUOPan,WANG Wei-nan,WEI Yuan. Effects of Glycyrrhizae Radix etRhizoma and honey-fried Glycyrrhizae Radix et Rhizoma on mouse liver CYP3As and detoxification of triptolide. Chinese Traditional Patent Medicine.2014, 36(12):2451-2457.

10.Wei Y, Li L, Zhou X, Zhang QY, Dunbar A, Liu F, Kluetzman K, Yang W, Ding X.Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model. Drug MetabDispos. 2013 Jan;41(1):132-40.

11.Li L, Wei Y, Zhou X, et al. Characterization of a Cyp2a (4/5) bgs-null Mouse Model: Role of CYP2A and CYP2B in Nicotine Metabolism[J]. The FASEB Journal, 2012, 26(1 Supplement): 1052.3-1052.3.

12.Wei Y, Wu H, Li L, Liu Z, Zhou X, Weng Y, D'Agostino J, Ling G, Zhang L, Kluetzman K, Yao Y, Zhang QY, and Ding X Generation and characterization of a CYP 2A 13/2B6/ 2F 1 -transgenic mouse model. Drug MetabDispos.2012 Jun;40(6):1144-50.

13.Cao X, Deng W, Wei Y, Yang Y, Su W, Wei Y, Xu X, Yu J.IncorporatingpTGF-1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells for chondrogenicdifferentiation.Eur Cell Mater. 2012 Feb 7;23:81-93.

14.Li L*, Wei Y *, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and characterization of a Cyp 2f 2-null mouse and studies on the role of CYP 2F 2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa. J PharmacolExpTher.2011 Oct;339(1):62-71. (* Co-first author ).

15.Tong S, Chu C , Wei Y , Wang L, Gao X, Xu X, Yu J.Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger. J Pharm Pharmacol.2011 Feb;63(2):238-44.

16.Zhou X, Wei Y, Xie F, Laukaitis CM, Karn RC, Kluetzman K, Gu J, Zhang QY, Roberts DW, Ding X. A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP 2A 5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression. MolPharmacol.2011 Apr;79(4):710-23.

17.Wei Y , Zhou X, Fang C, Li L, Kluetzman K, Yang W, Zhang QY, Ding X.Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues. J PharmacolExpTher.2010 Jul;334(1):69-77.

18.Ling G, Wei Y , and Ding X. Transcriptional regulation of human CYP 2A 13 expression in the respiratory tract by CCAAT/enhancer binding protein and epigenetic modulation. MolPharmacol.2007, 71(3): 807-16;

19.Gu J, Chen CS, Wei Y , Fang C, Xie F, Kannan K, Yang W, Waxman DJ, and Ding X. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. J PharmacolExpTher.2007, 321(1): 9-17;

20.Wei Y , Zhou X, Ling GY, Zhang L, D'Agostino J, Kluetzman K, and Ding X Generation and characterization of a human CYP 2A 13 transgenic mouse model. DRUG METABOLISM REVIEWS 2006, 38(S2) 54-54

21.Zhao SW, Shen PP, Zhou Y, Wei Y , Xin XB, and Hua ZC. Selecting peptide ligands of microcystin-LR from phage displayed random libraries. Environ Int. 2005,31(4): 535-41.

Authorized invention patent:

Smoking population lung cancer risk - related cytochrome P450 gene detection chip(ZL201110123137.2)

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Address:School of Pharmacy,Jiangsu University,Zhenjiang,Jiangsu,P.R.China,Post  Tel:+86-511-85038451-805 Fax:+86-511-85038451-806 E-mail:phar@ujs.edu.cn
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